Pre-market: PharmaNet Development Group, Salix Pharmaceuticals and Shutterfly lead small-cap volume

PharmaNet Development Group Inc. (Nasdaq:PDGI), Salix Pharmaceuticals, Ltd. (Nasdaq:SLXP) and Shutterfly, Inc. (Nasdaq:SFLY) are among the most actively traded companies in Thursday's pre-market trading among those with market capitalizations under $750 million.

Jos. A. Bank Clothiers, Inc. (Nasdaq:JOSB), CV Therapeutics, Inc. (Nasdaq:CVTX) and InterMune, Inc. (Nasdaq:ITMN) are also among the most actively traded small-cap companies in pre-market trading.

Here are the most actively traded small-cap companies in Thursday's pre-market trading:

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