Helicos BioSciences Corp. (Nasdaq:HLCS), EXFO Electro-Optical Engineering (Nasdaq:EXFO) and Green Plains Renewable Energy Inc. (Nasdaq:GPRE) are among the biggest percentage gainers in Wednesday's trading among companies with market capitalizations under $750 million.

Evans Bancorp Inc. (Nasdaq:EVBN), Packeteer, Inc. (Nasdaq:PKTR) and The Talbots, Inc. (NYSE:TLB) are also among the top small-cap percentage gainers.

Here are Wednesday's biggest percentage gainers:

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